A Republican Senate nominee found himself in hot water on Sunday for suggesting that instances of "legitimate rape" rarely results in pregnancy.

Rep. Todd Akin, a Republican who's locked in a hard-fought campaign in Missouri to unseat Democratic Sen. Claire McCaskill, was answering a question regarding his position on abortion rights in instances when a woman is a victim of rape.

"People always want to make it into one of those things — well, how do you slice this particularly tough ethical question," Akin said in an interview on KTVI-TV, video of which was circulated by the Democratic super PAC American Bridge.

“First of all, from what I understand from doctors, [pregnancy from rape] is really rare. If it’s a legitimate rape, the female body has ways to try to shut that whole thing down," Akin said.

Regarding his opinion on whether to allow for an abortion in such instances, Akin added: “But let’s assume that maybe that didn’t work or something. I think there should be some punishment, but the punishment ought to be on the rapist and not attacking the child.”

Akin's comments had an almost immediate impact on Missouri's Senate race. McCaskill wrote on Twitter:

"In reviewing my off-the-cuff remarks, it's clear that I misspoke in this interview and it does not reflect the deep empathy I hold for the thousands of women who are raped and abused every year," he said.

Akin emerged earlier this month from a tough three-way primary in Missouri, where he rallied social conservatives behind his candidacy. Democrats actually spent during that primary to help Akin win, viewing the six-term congressman as a less formidable challenger in the general election.

McCaskill, who was first elected in 2006, has become a top target for Republicans this fall, given President Barack Obama's unpopularity in the state and successive statewide victories for the GOP.